cAMPS-Rp, triethylammonium salt

Name: cAMPS-Rp, triethylammonium salt
Brand: Tocris Bioscience
SKU: 1337

Tocris Bioscience, part of Bio-Techne | Catalog # 1337

(1)

Citations (30)

COA / SDS

cAMP antagonist

Key Product Details

Chemical Name:	(R)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium
Purity:	≥98%
Molecular Weight:	446.46 kDa

View Full Technical Details for cAMPS-Rp, triethylammonium salt

Technical Data
Citations / Reviews (1)

Biological Activity for cAMPS-Rp, triethylammonium salt

cAMPS-Rp, triethylammonium salt is a cell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC₅₀ = 11 - 16 μM) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases.

Technical Data for cAMPS-Rp, triethylammonium salt

M. Wt	446.46 kDa
Formula	C₁₀H₁₂N₅O₅PS.C₆H₁₅N
Storage	Store at -20°C
Purity	≥98%
CAS Number	151837-09-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for cAMPS-Rp, triethylammonium salt

Solubility

Soluble Soluble to 100 mM in water

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References for cAMPS-Rp, triethylammonium salt

References are publications that support the biological activity of the product.

J Mitlöhner, R Kaushik, H Niekisch, A Blondiaux, CE Gee, MFK Happel, E Gundelfing, A Dityatev, R Frischknec, C Seidenbech Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses Cells, 2020;9(2):. 2020 PMID: 31972963
W Cao, Y Xu, D Luo, M Saeed, C Sun Hoxa5 Promotes Adipose Differentiation via Increasing DNA Methylation Level and Inhibiting PKA/HSL Signal Pathway in Mice Cell. Physiol. Biochem., 2018;45(3):1023-1033. 2018 PMID: 29439250
Belgacem Y, Borodinsky L Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Proc Natl Acad Sci U S A, 2015;112(13):4140-5. 2015 PMID: 25829542
D Schlam, J Canton, M Carreño, H Kopinski, SA Freeman, S Grinstein, GD Fairn Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis MBio, 2016;7(2):. 2016 PMID: 27048806
Duca et al. MetF. activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat.Med., 2015;21:506 PMID: 25849133
Fu et al. PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol.Pain, 2008;4:26 PMID: 18631385
Dostmann et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem., 1990;265:10484 PMID: 2162349
Kuriyama et al. Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest.Ophthalmol.Vis.Sci., 1995;36:730 PMID: 7890503
Rothermel and Botelho A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem.J., 1988;251:757 PMID: 2843164
Van Haastert et al. Competitive cAMP antagonists for cAMP-receptor proteins. J.Biol.Chem., 1984;259:10020 PMID: 6088478