Canertinib dihydrochloride

Name: Canertinib dihydrochloride
Brand: Tocris Bioscience
SKU: 5916

Tocris Bioscience, part of Bio-Techne | Catalog # 5916

Citations (1)

COA / SDS

Potent EGFR kinase inhibitor

Key Product Details

Description:	Potent EGFR kinase inhibitor
Alternative Names:	CI 1033,PD 183805
Chemical Name:	N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	558.86

View Full Technical Details for Canertinib dihydrochloride

Technical Data
Citations

Biological Activity for Canertinib dihydrochloride

Canertinib dihydrochloride is a potent EGFR kinase inhibitor (IC₅₀ = 7.4 nM). Blocks autophosphorylation of erbB2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Canertinib dihydrochloride

M. Wt	558.86
Formula	C₂₄H₂₅ClFN₅O_3.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	289499-45-2
PubChem ID	156413
InChi Key	JZZFDCXSFTVOJY-UHFFFAOYSA-N
Smiles	O=C(C=C)NC1=C(OCCCN4CCOCC4)C=C(N=CN=C2NC3=CC(Cl)=C(F)C=C3)C2=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Canertinib dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	11.18	20
	DMSO	55.89	100

Preparing Stock Solutions for Canertinib dihydrochloride

The following data is based on the product molecular weight 558.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.79 mL	8.95 mL	17.89 mL
5 mM	0.36 mL	1.79 mL	3.58 mL
10 mM	0.18 mL	0.89 mL	1.79 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for Canertinib dihydrochloride

References are publications that support the biological activity of the product.

Smaill Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J.Med.Chem. 2000 PMID: 10753475