Carbamazepine

Name: Carbamazepine
Brand: Tocris Bioscience
SKU: 4098
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4098

(1)

Citations (17)

COA / SDS

Inhibitor of neuronal NaV channels; anticonvulsant

Key Product Details

Description:	Inhibitor of neuronal Na_V channels; anticonvulsant
Alternative Names:	CBZ
Chemical Name:	5H-Dibenz[b,f]azepine-5-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	236.27

View Full Technical Details for Carbamazepine

Technical Data
Citations / Reviews (1)

Biological Activity for Carbamazepine

Carbamazepine is an inhibitor of neuronal voltage-gated Na⁺ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl^- currents in HEK 293 cells expressing the GABA_A receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis. Also delays disease onset and prolongs survival in a mouse amyotrophic lateral sclerosis (ALS) model, as well as reducing motor neuron loss and altered muscle morphology.

Compound Libraries for Carbamazepine

Carbamazepine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Carbamazepine

M. Wt	236.27
Formula	C₁₅H₁₂N₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	298-46-4
PubChem ID	2554
InChi Key	FFGPTBGBLSHEPO-UHFFFAOYSA-N
Smiles	NC(N1C3=C(C=CC=C3)C=CC2=C1C=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Carbamazepine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.63	100
	ethanol	5.91	25

Preparing Stock Solutions for Carbamazepine

The following data is based on the product molecular weight 236.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.23 mL	21.16 mL	42.32 mL
5 mM	0.85 mL	4.23 mL	8.46 mL
10 mM	0.42 mL	2.12 mL	4.23 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

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Reconstitution Calculator

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References for Carbamazepine

References are publications that support the biological activity of the product.

Zhang Repurposing carbamaz. for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model. CNS Neurosci.Ther. 2018 PMID: 29656576
Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
Sarkar Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 2009 PMID: 18636076
Lipkind and Fozzard Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol.Pharmacol. 2010 PMID: 20643904
Afanas'ev Lamotrigine and carbamaz. affect differently the release of D-[³H] aspartate from mouse cerebral cortex slices: involvement of NO. Neurochem.Res. 1999 PMID: 10485587
Granger Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamaz. and phen. Mol.Pharmacol. 1995 PMID: 7603459

Product Documents for Carbamazepine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Carbamazepine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov