Cardamonin

Name: Cardamonin
Brand: Tocris Bioscience
SKU: 2509

Tocris Bioscience, part of Bio-Techne | Catalog # 2509

Citations (14)

COA / SDS

Inhibitor of NF-κB activation; anti-inflammatory

Key Product Details

Description:	Inhibitor of NF-κB activation; anti-inflammatory
Chemical Name:	(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	270.28

View Full Technical Details for Cardamonin

Technical Data
Citations

Biological Activity for Cardamonin

Cardamonin is a chalone analog that display anti-inflammatory activity. Inhibits NO and PGE₂ production from LPS- and IFN-γ-induced RAW cells and inhibits TXB₂ production via the COX-1 and COX-2 pathways. Inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.

Compound Libraries for Cardamonin

Cardamonin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Cardamonin

M. Wt	270.28
Formula	C₁₆H₁₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	19309-14-9
PubChem ID	641785
InChi Key	NYSZJNUIVUBQMM-BQYQJAHWSA-N
Smiles	OC1=CC(O)=C(C(/C=C/C2=CC=CC=C2)=O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cardamonin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.03	100
	ethanol	5.41	20

Preparing Stock Solutions for Cardamonin

The following data is based on the product molecular weight 270.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.70 mL	18.50 mL	37.00 mL
5 mM	0.74 mL	3.70 mL	7.40 mL
10 mM	0.37 mL	1.85 mL	3.70 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for Cardamonin

References are publications that support the biological activity of the product.

Ahmad Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Eur.J.Pharmacol. 2006 PMID: 16650843
Israf Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells. Mol.Immunol. 2007 PMID: 16777230
Lee Blockade of nuclear factor-κB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera. J.Pharmacol.Exp.Ther. 2006 PMID: 16183703