CBMR 0083

Name: CBMR 0083
Brand: Tocris Bioscience
SKU: 7890

Tocris Bioscience, part of Bio-Techne | Catalog # 7890

Citations (1)

COA / SDS

Potent allosteric FFA1 (GPR40) and 4 (GPR120) agonist

Key Product Details

Description:	Potent allosteric FFA1 (GPR40) and 4 (GPR120) agonist
Chemical Name:	1-[3-[[4-Amino-6-[[2-(2,5-dichlorophenyl)ethyl]amino]-1,3,5-triazin-2-yl]methoxy]-5-methylphenyl]-2-pyrrolidinone
Purity:	≥98% (HPLC)
Molecular Weight:	487.39

View Full Technical Details for CBMR 0083

Technical Data
Citations

Biological Activity for CBMR 0083

CBMR 0083 is a potent allosteric free fatty acid receptor 1 (FFA1) and 4 (FFA4) agonist (EC₅₀ values are 1 and 2 nM for FFA1 and FFA4, respectively).

Technical Data for CBMR 0083

M. Wt	487.39
Formula	C₂₃H₂₄Cl₂N₆O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2839486-16-5
PubChem ID	167312323
InChi Key	AIIZGUNRDJPXHF-UHFFFAOYSA-N
Smiles	O=C1N(CCC1)C2=CC(OCC3=NC(NCCC4=CC(Cl)=CC=C4Cl)=NC(N)=N3)=CC(C)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CBMR 0083

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.74	100

Preparing Stock Solutions for CBMR 0083

The following data is based on the product molecular weight 487.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.26 mL	20.52 mL
5 mM	0.41 mL	2.05 mL	4.10 mL
10 mM	0.21 mL	1.03 mL	2.05 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for CBMR 0083

References are publications that support the biological activity of the product.

Lückmann Optimization of first-in-class dual-acting FFAR1/FFAR4 allosteric modulators with novel mode of action. ACS Med.Chem.Lett. 2022 PMID: 36518697