CC 401 dihydrochloride

Name: CC 401 dihydrochloride
Brand: Tocris Bioscience
SKU: 6258

Tocris Bioscience, part of Bio-Techne | Catalog # 6258

Citations (1)

COA / SDS

High affinity JNK inhibitor; also inhibits HCMV replication

Key Product Details

Description:	High affinity JNK inhibitor; also inhibits HCMV replication
Chemical Name:	3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	461.39

View Full Technical Details for CC 401 dihydrochloride

Technical Data
Citations

Biological Activity for CC 401 dihydrochloride

CC 401 dihydrochloride is a high affinity JNK inhibitor (K_i values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication.

Compound Libraries for CC 401 dihydrochloride

CC 401 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for CC 401 dihydrochloride

M. Wt	461.39
Formula	C₂₂H₂₄N₆O.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2250025-96-6
PubChem ID	66576998
InChi Key	LDUPODIOUWRGCQ-UHFFFAOYSA-N
Smiles	N1(CCCCC1)CCOC2=CC=CC(C3=NNC4=CC=C(C5=NN=CN5)C=C34)=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CC 401 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	46.14	100
	DMSO	46.14	100

Preparing Stock Solutions for CC 401 dihydrochloride

The following data is based on the product molecular weight 461.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.84 mL	21.67 mL
5 mM	0.43 mL	2.17 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for CC 401 dihydrochloride

References are publications that support the biological activity of the product.

Vasilevskaya Inhibition of JNK sensitizes hypoxic colon cancer cells to DNA-damaging agents. Clin.Cancer.Res. 2015 PMID: 26023085
Zhang The c-Jun N-terminal kinase inhibitor SP600125 inhibits human cytomegalovirus replication. J.Med.Virol. 2015 PMID: 26058558
Ma Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab.Invest. 2009 PMID: 19188913
Ma A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J.Am.Soc.Nephrol. 2007 PMID: 17202416
Uehara JNK mediates hepatic ischemia reperfusion injury. J.Hepatol. 2005 PMID: 15885356
Uehara c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 2004 PMID: 15316358