CCMI

Name: CCMI
Brand: Tocris Bioscience
SKU: 3837

Tocris Bioscience, part of Bio-Techne | Catalog # 3837

Citations (2)

COA / SDS

Positive allosteric modulator of α7 nAChRs

Key Product Details

Description:	Positive allosteric modulator of α7 nAChRs
Alternative Names:	XY 4083
Chemical Name:	[N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide
Molecular Weight:	388.25

View Full Technical Details for CCMI

Technical Data
Citations

Biological Activity for CCMI

CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC₅ currents (EC₅₀ = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

Compound Libraries for CCMI

CCMI is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CCMI

M. Wt	388.25
Formula	C₁₉H₁₅Cl₂N₃O₂
Storage	Store at -20°C
CAS Number	917837-54-8
PubChem ID	67042344
InChi Key	VMAKIACTLSBBIY-UHFFFAOYSA-N
Smiles	CC1=NOC(=C1)C(=CNC1=CC=C(Cl)C=C1)C(=O)NC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CCMI

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.83	100
	ethanol	3.88	10

Preparing Stock Solutions for CCMI

The following data is based on the product molecular weight 388.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.58 mL	12.88 mL	25.76 mL
5 mM	0.52 mL	2.58 mL	5.15 mL
10 mM	0.26 mL	1.29 mL	2.58 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CCMI

References are publications that support the biological activity of the product.

Hu Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. Br.J.Pharmacol. 2009 PMID: 20050184
Ng Nootropic α7 nicotinic receptor allosteric modulator derived from GABA_A receptor modulators. Proc.Natl.Acad.Sci.U.S.A. 2007 PMID: 17470817
Gronlien Distinct profiles of α₇ nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 2007 PMID: 17565004