CCT 241533 dihydrochloride

Name: CCT 241533 dihydrochloride
Brand: Tocris Bioscience
SKU: 4968

Tocris Bioscience, part of Bio-Techne | Catalog # 4968

Citations (4)

COA / SDS

Potent Chk2 inhibitor

Key Product Details

Description:	Potent Chk2 inhibitor
Chemical Name:	(3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	515.41

View Full Technical Details for CCT 241533 dihydrochloride

Technical Data
Citations

Biological Activity for CCT 241533 dihydrochloride

CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC₅₀ = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

Licensing Information

Sold under license from Cancer Research Technology Ltd (Ximbio).

Compound Libraries for CCT 241533 dihydrochloride

CCT 241533 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CCT 241533 is reviewed on the chemical probes website.

Technical Data for CCT 241533 dihydrochloride

M. Wt	515.41
Formula	C₂₃H₂₇FN₄O₄.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1962925-28-5
PubChem ID	49867844
InChi Key	IXTQNANZDPZION-GSOOIIRJSA-N
Smiles	FC1=CC(C3=NC2=CC(OC)=C(OC)C=C2C(N[C@H]4[C@H]([C@](C)(O)C)CNC4)=N3)=C(O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CCT 241533 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	5.15	10 with gentle warming
	DMSO	51.54	100

Preparing Stock Solutions for CCT 241533 dihydrochloride

The following data is based on the product molecular weight 515.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.70 mL	19.40 mL
5 mM	0.39 mL	1.94 mL	3.88 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for CCT 241533 dihydrochloride

References are publications that support the biological activity of the product.

Caldwell Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 2011 PMID: 21186793