CD 3254

Name: CD 3254
Brand: Tocris Bioscience
SKU: 3302

Tocris Bioscience, part of Bio-Techne | Catalog # 3302

Citations (12)

COA / SDS

Potent and selective RXRα agonist

Key Product Details

Description:	Potent and selective RXRα agonist
Chemical Name:	3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoic acid
Purity:	≥97% (HPLC)
Molecular Weight:	364.48

View Full Technical Details for CD 3254

Technical Data
Citations

Biological Activity for CD 3254

CD 3254 is a selective RXRα agonist; exhibits no activity at RARα, RARβ or RARγ receptors. CD 3254 can promote chemical reprogramming of mouse fibroblasts. In a fast chemical reprogramming protocol, it promotes reprogramming of foetal mouse dorsal fibroblasts (MDFs) and adult mouse lung fibroblasts (MLFs) to iPS cells within 12 days.

Compound Libraries for CD 3254

CD 3254 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CD 3254

M. Wt	364.48
Formula	C₂₄H₂₈O₃
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	196961-43-0
PubChem ID	44566110
InChi Key	DYLLZSVPAUUSSB-VQHVLOKHSA-N
Smiles	CC1(C)C2=C(C=C(C3=C(O)C=CC(/C=C/C(O)=O)=C3)C(C)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CD 3254

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.45	100
	ethanol	36.45	100

Preparing Stock Solutions for CD 3254

The following data is based on the product molecular weight 364.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.72 mL	27.44 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for CD 3254

References are publications that support the biological activity of the product.

Chen A fast chemical reprogramming system promotes cell identity transition through a diapause-like state. Nat.Cell Biol. 2023 PMID: 37550515
Jin Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception. Proc.Natl.Acad.Sci. 2023 PMID: 37192170
le Maire Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO.Rep. 2009 PMID: 19270714
Nahoum Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci. 2007 PMID: 17947383
Pogenberg Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. J.Biol.Chem. 2005 PMID: 15528208