CDDO Im

Name: CDDO Im
Brand: Tocris Bioscience
SKU: 4737

Tocris Bioscience, part of Bio-Techne | Catalog # 4737

Citations (14)

COA / SDS

Nrf2 signaling activator

Key Product Details

Description:	Nrf2 signaling activator
Chemical Name:	1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole
Purity:	≥98% (HPLC)
Molecular Weight:	541.72

View Full Technical Details for CDDO Im

Technical Data
Citations

Biological Activity for CDDO Im

CDDO Im is an Nrf2 signaling activator; increases Nrf2 protein expression and enhances Nrf2-dependent cytoprotective gene expression. CDDO Im inhibits cell growth and induces apoptosis of pancreatic cancer cells in vitro. Also reduces acetaminophen-induced liver injury in mice.

Compound Libraries for CDDO Im

CDDO Im is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CDDO Im

M. Wt	541.72
Formula	C₃₄H₄₃N₃O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	443104-02-7
PubChem ID	9958995
InChi Key	ITFBYYCNYVFPKD-FMIDTUQUSA-N
Smiles	O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]4(C)[C@]([H])3[C@@]5([H])[C@@](CCC(C)(C)C5)([C@](N6C=NC=C6)=O)CC4)(C)C2=CC3=O)([H])C(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CDDO Im

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.17	100

Preparing Stock Solutions for CDDO Im

The following data is based on the product molecular weight 541.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.23 mL	18.46 mL
5 mM	0.37 mL	1.85 mL	3.69 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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References for CDDO Im

References are publications that support the biological activity of the product.

Samudio 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J.Biol.Chem. 2005 PMID: 16118208
Aleksunes Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. J.Pharmacol.Exp.Ther. 2010 PMID: 20605904
Reisman CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. Toxicol.Appl.Pharmacol. 2009 PMID: 19371629