CDPPB

Name: CDPPB
Brand: Tocris Bioscience
SKU: 3235

Tocris Bioscience, part of Bio-Techne | Catalog # 3235

Citations (27)

COA / SDS

Positive allosteric modulator of mGlu5 receptors

Key Product Details

Description:	Positive allosteric modulator of mGlu₅ receptors
Chemical Name:	3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	364.4

View Full Technical Details for CDPPB

Technical Data
Citations

Biological Activity for CDPPB

CDPPB is a brain penetrant, selective positive allosteric modulator at the mGlu₅ receptor (EC₅₀ values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.

Licensing Information

Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

Compound Libraries for CDPPB

CDPPB is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CDPPB

M. Wt	364.4
Formula	C₂₃H₁₆N₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	781652-57-1
PubChem ID	11245456
InChi Key	BKUIZWILNWHFHD-UHFFFAOYSA-N
Smiles	O=C(C4=CC(C#N)=CC=C4)NC1=CC(C3=CC=CC=C3)=NN1C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CDPPB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	27.33	75

Preparing Stock Solutions for CDPPB

The following data is based on the product molecular weight 364.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.66 mL	18.29 mL	36.59 mL
3.75 mM	0.73 mL	3.66 mL	7.32 mL
7.5 mM	0.37 mL	1.83 mL	3.66 mL
37.5 mM	0.07 mL	0.37 mL	0.73 mL

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References for CDPPB

References are publications that support the biological activity of the product.

Kinney A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rats behavioral models. J.Pharmacol.Exp.Ther. 2005 PMID: 15608073
Chen Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol.Pharmacol. 2007 PMID: 17303702
Lindsley Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides that potentiate receptor function in vivo. J.Med.Chem. 2004 PMID: 15537338