CGI 1746

Name: CGI 1746
Brand: Tocris Bioscience
SKU: 6965

Tocris Bioscience, part of Bio-Techne | Catalog # 6965

COA / SDS

Potent, reversible BTK inhibitor

Key Product Details

Description:	Potent, reversible BTK inhibitor
Chemical Name:	N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)benzamide
Purity:	≥97%
Molecular Weight:	579.7

View Full Technical Details for CGI 1746

Technical Data
Citations

Biological Activity for CGI 1746

CGI 1746 is a potent, reversible inhibitor of Bruton's tyrosine kinase (Btk) (IC₅₀ = 1.9 nM). CGI 1746 decreases cell survival in prostate cancer cell lines. In a cell model, CGI 1746 blocks the production of FcγR-induced cytokines IL-1β, TNFα and IL-6 (IC₅₀ values are 36 nM, 47 nM and 353 nM, respectively).

Technical Data for CGI 1746

M. Wt	579.7
Formula	C₃₄H₃₇N₅O₄
Storage	Store at -20°C
Purity	≥97%
CAS Number	910232-84-7
PubChem ID	24857323
InChi Key	JIFCFQDXHMUPGP-UHFFFAOYSA-N
Smiles	CN1C=C(N=C(NC2=CC=C(C=C2)C(=O)N2CCOCC2)C1=O)C1=C(C)C(NC(=O)C2=CC=C(C=C2)C(C)(C)C)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGI 1746

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	11.59	20
	DMSO	2.9	5

Preparing Stock Solutions for CGI 1746

The following data is based on the product molecular weight 579.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.63 mL	43.13 mL	86.25 mL
1 mM	1.73 mL	8.63 mL	17.25 mL
2 mM	0.86 mL	4.31 mL	8.63 mL
10 mM	0.17 mL	0.86 mL	1.73 mL

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References for CGI 1746

References are publications that support the biological activity of the product.

Kokabee Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer. Cancer Biol. Ther. 2015 PMID: 26383180
Di Paolo Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat.Chem.Biol. 2011 PMID: 21113169