CGK 733

Name: CGK 733
Brand: Tocris Bioscience
SKU: 2639

Tocris Bioscience, part of Bio-Techne | Catalog # 2639

Citations (6)

COA / SDS

Induces apoptosis in prematurely senescent cells

Discontinued Product

2639 has been discontinued. View all ATM and ATR Kinase Inhibitors products.

Key Product Details

Description:	Induces apoptosis in prematurely senescent cells
Chemical Name:	α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	555.84

View Full Technical Details for CGK 733

Technical Data
Citations

Biological Activity for CGK 733

Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21^CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.

Technical Data for CGK 733

M. Wt	555.84
Formula	C₂₃H₁₈Cl₃FN₄O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	905973-89-9
PubChem ID	6605258
InChi Key	HLCDNLNLQNYZTK-UHFFFAOYSA-N
Smiles	[O-][N+](=O)C1=CC(NC(=S)NC(NC(=O)C(C2=CC=CC=C2)C2=CC=CC=C2)C(Cl)(Cl)Cl)=CC=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CGK 733

References are publications that support the biological activity of the product.

Won Retraction: small molecule-based reversible reprogramming of cellular lifespan. Nat.Chem.Biol. 2008 PMID: 18560433
Bhattacharya Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Cell Signal. 2009 PMID: 19136059
Alao and Sunnerhagen The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat.Oncol. 2009 PMID: 19903334
Crescenzi Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy. Clin.Cancer Res. 2008 PMID: 18347191

CGK 733

Tocris Bioscience, part of Bio-Techne | Catalog # 2639

Key Product Details

Biological Activity for CGK 733

Technical Data for CGK 733

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for CGK 733

Product Documents for CGK 733

COA

Certificate of Analysis

SDS

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