CGP 37157

Name: CGP 37157
Brand: Tocris Bioscience
SKU: 1114

Tocris Bioscience, part of Bio-Techne | Catalog # 1114

Citations (123)

COA / SDS

Antagonist of mitochondrial Na+/Ca2+ exchange

Key Product Details

Description:	Antagonist of mitochondrial Na⁺/Ca²⁺ exchange
Chemical Name:	7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
Purity:	≥99% (HPLC)
Molecular Weight:	324.22

View Full Technical Details for CGP 37157

Technical Data
Citations

Biological Activity for CGP 37157

CGP 37157 is a selective antagonist of the mitochondrial Na⁺/Ca²⁺ exchanger (NCX; IC₅₀ = 0.4 μM).

Compound Libraries for CGP 37157

CGP 37157 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CGP 37157

M. Wt	324.22
Formula	C₁₅H₁₁Cl₂NOS
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	75450-34-9
PubChem ID	2688
InChi Key	KQEPIRKXSUIUTH-UHFFFAOYSA-N
Smiles	ClC1=CC=C2NC(=O)CSC(C3=CC=CC=C3Cl)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 37157

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for CGP 37157

The following data is based on the product molecular weight 324.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.42 mL	30.84 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for CGP 37157

References are publications that support the biological activity of the product.

White and Reynolds Mitochondria accumulate Ca²⁺ following intense glutamate stimulation of cultured rat forebrain neurones. J.Physiol. 1997 PMID: 9023766
Cox Selectivity of inhibition of Na⁺-Ca²⁺ exchange of heart mitochondria by benzothiazepine CGP-37157. J.Cardiovasc.Pharmacol. 1993 PMID: 7681905
Cox and Matlib Modulation of intramitochondrial free Ca²⁺ concentration by antagonists of Na⁺-Ca²⁺ exchange. TiPS 1993 PMID: 8296399
Baron and Thayer CGP37157 modulates mitochondrial Ca²⁺ homeostasis in cultured rat dorsal root ganglion neurons. Eur.J.Pharmacol. 1997 PMID: 9537826