CGP 46381

Name: CGP 46381
Brand: Tocris Bioscience
SKU: 1247

Tocris Bioscience, part of Bio-Techne | Catalog # 1247

Citations (27)

COA / SDS

Selective GABAB antagonist; brain penetrant

Key Product Details

Description:	Selective GABA_B antagonist; brain penetrant
Chemical Name:	(3-Aminopropyl)(cyclohexylmethyl)phosphinic acid
Molecular Weight:	219.26

View Full Technical Details for CGP 46381

Technical Data
Citations

Biological Activity for CGP 46381

CGP 46381 is a brain penetrant, selective GABA_B receptor antagonist (IC₅₀ = 4.9 μM).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data for CGP 46381

M. Wt	219.26
Formula	C₁₀H₂₂NO₂P
Storage	Store at RT
CAS Number	123691-14-5
PubChem ID	130022
InChi Key	XOESDNIUAWGCLU-UHFFFAOYSA-N
Smiles	NCCCP(CC1CCCCC1)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 46381

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	21.93	100

Preparing Stock Solutions for CGP 46381

The following data is based on the product molecular weight 219.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.56 mL	22.80 mL	45.61 mL
5 mM	0.91 mL	4.56 mL	9.12 mL
10 mM	0.46 mL	2.28 mL	4.56 mL
50 mM	0.09 mL	0.46 mL	0.91 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CGP 46381

References are publications that support the biological activity of the product.

Froestl Potent, orally active GABA_B receptor antagonists. Pharmacol.Rev.Comm.
Staubli GABA_B receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 1999 PMID: 10341258
Lingenhoehl and Olpe Blockade of the late inhibitory postsynaptic potential in vivo by the GABA_B antagonist CGP 46381. Pharmacol.Comm.
Curtis and Lacey Prolonged GABA_B receptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study. Exp.Brain Res. 1998 PMID: 9746138