CGP 53353

Name: CGP 53353
Brand: Tocris Bioscience
SKU: 2442

Tocris Bioscience, part of Bio-Techne | Catalog # 2442

Citations (14)

COA / SDS

Selective inhibitor of PKCβII

Key Product Details

Chemical Name:	5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione
Purity:	≥99%
Molecular Weight:	365.34 kDa

View Full Technical Details for CGP 53353

Technical Data
Citations

Biological Activity for CGP 53353

CGP 53353 is a selective inhibitor of PKCβII (IC₅₀ values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC₅₀ ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.

Technical Data for CGP 53353

M. Wt	365.34 kDa
Formula	C₂₀H₁₃F₂N₃O₂
Storage	Store at RT
Purity	≥99%
CAS Number	145915-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 53353

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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References for CGP 53353

References are publications that support the biological activity of the product.

Kouroedov et al. Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation, 2004;110:91 PMID: 15210597
Wang et al. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci.USA, 2008;105:7159