CHC

Tocris Bioscience, part of Bio-Techne | Catalog # 5029

COA / SDS

MCT inhibitor; decreases glycoloysis

Key Product Details

Chemical Name:	2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
Purity:	≥98%

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Technical Data
Citations

Biological Activity for CHC

CHC is a monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide (Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.

Technical Data for CHC

Formula	C₁₀H₇NO₃
Storage	Store at +4°C
Purity	≥98%
CAS Number	28166-41-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHC

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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References for CHC

References are publications that support the biological activity of the product.

Colen et al. Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. Neurosurgery, 2006;59:1313 PMID: 17277695
Miranda-Gonçalves et al. Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. Neuro.Oncol., 2013;15:172 PMID: 23258846
Fang et al. The H⁺-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol.Pharmacol., 2006;70:2108 PMID: 17000864
Dimmer et al. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem.J., 2000;350:219 PMID: 10926847

CHC

Tocris Bioscience, part of Bio-Techne | Catalog # 5029

Key Product Details

Biological Activity for CHC

Technical Data for CHC

Solubility for CHC

Dilution Calculator

Reconstitution Calculator

References for CHC

Product Documents for CHC

COA

Certificate of Analysis

SDS

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