CHDI 113

Name: CHDI 113
Brand: Tocris Bioscience
SKU: 8063

Tocris Bioscience, part of Bio-Techne | Catalog # 8063

COA / SDS

Potent HTT pre-RNA splicing modulator

Key Product Details

Description:	Potent HTT pre-RNA splicing modulator
Chemical Name:	5-[(3R)-3-(Cyclopropylamino)-1-pyrrolidinyl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-pyrazinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	395.44

View Full Technical Details for CHDI 113

Technical Data
Citations

Biological Activity for CHDI 113

CHDI 113 is a potent huntingtin (HTT) pre-mRNA splicing modulator (EC₅₀ = 66 nM). It lowers HTT protein in both human Huntington's disease (HD) stem cells and in the brain of BACHD (bacterial artificial chromosome-mediated transgenic) mouse model. CHDI 113 is brain penetrant and orally bioavailable.

Licensing Information

Sold under license from CHDI Foundation

Technical Data for CHDI 113

M. Wt	395.44
Formula	C₂₀H₂₂FN₇O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2743336-70-9
PubChem ID	166508076
InChi Key	VPWHAEPYJSEFEH-CQSZACIVSA-N
Smiles	FC1=CC(NC(C2=NC=C(N3C[C@@H](CC3)NC4CC4)N=C2)=O)=CN5C1=NC(C)=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHDI 113

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.54	100

Preparing Stock Solutions for CHDI 113

The following data is based on the product molecular weight 395.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.64 mL	25.29 mL
5 mM	0.51 mL	2.53 mL	5.06 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for CHDI 113

References are publications that support the biological activity of the product.

Liu Identification and optimization of RNA-splicing modulators as Huntingtin protein-lowering agents for the treatment of Huntington's disease. J.Med.Chem. 2023 PMID: 37712656