CHPG Sodium salt

Name: CHPG Sodium salt
Brand: Tocris Bioscience
SKU: 3695

Tocris Bioscience, part of Bio-Techne | Catalog # 3695

Citations (3)

COA / SDS

Selective mGlu5 agonist; sodium salt of CHPG (Cat. No. 1049)

Key Product Details

Description:	Selective mGlu₅ agonist; sodium salt of CHPG (Cat. No. 1049)
Chemical Name:	(RS)-2-Chloro-5-hydroxyphenylglycine sodium salt
Purity:	≥99% (HPLC)
Molecular Weight:	223.59

View Full Technical Details for CHPG Sodium salt

Technical Data
Citations

Biological Activity for CHPG Sodium salt

CHPG Sodium salt is a sodium salt of the selective mGlu₅ agonist CHPG (Cat. No. 1049).

Compound Libraries for CHPG Sodium salt

CHPG Sodium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CHPG Sodium salt

M. Wt	223.59
Formula	C₈H₇ClNNaO₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1303993-73-8
PubChem ID	52974246
InChi Key	KZRZZIISUUINJT-UHFFFAOYSA-M
Smiles	[Na+].NC(C([O-])=O)C1=CC(O)=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHPG Sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	11.18	50
	DMSO	11.18	50

Preparing Stock Solutions for CHPG Sodium salt

The following data is based on the product molecular weight 223.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.94 mL	44.72 mL	89.45 mL
2.5 mM	1.79 mL	8.94 mL	17.89 mL
5 mM	0.89 mL	4.47 mL	8.94 mL
25 mM	0.18 mL	0.89 mL	1.79 mL

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Reconstitution Calculator

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References for CHPG Sodium salt

References are publications that support the biological activity of the product.

Salt Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 1999 PMID: 10455248
Bao Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 2001 PMID: 11743947
Doherty (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu₅, but not mGlu₁, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 1997 PMID: 9144665