CI 1020

Name: CI 1020
Brand: Tocris Bioscience
SKU: 2942

Tocris Bioscience, part of Bio-Techne | Catalog # 2942

COA / SDS

Highly selective, orally active ETA antagonist

Discontinued Product

2942 has been discontinued. View all Endothelin ETA Receptor Antagonists products.

Key Product Details

Description:	Highly selective, orally active ET_A antagonist
Alternative Names:	PD 156707
Chemical Name:	3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone
Purity:	≥98% (HPLC)
Molecular Weight:	506.5

View Full Technical Details for CI 1020

Technical Data
Citations

Biological Activity for CI 1020

CI 1020 is a highly selective, orally active, non-peptide endothelin-A receptor (ET_A) antagonist (IC₅₀ values are 0.3 and 480 nM for ET_A and ET_B receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CI 1020

M. Wt	506.5
Formula	C₂₈H₂₆O₉
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	162256-50-0
PubChem ID	9870830
InChi Key	PWIPORDFWDZCJG-UHFFFAOYSA-N
Smiles	O=C1C(C2=CC=C(OCO4)C4=C2)=C(CC3=CC(OC)=C(OC)C(OC)=C3)C(O)(C5=CC=C(OC)C=C5)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CI 1020

References are publications that support the biological activity of the product.

Jones The effect of the endothelin ET_A receptor antagonist CI-1020 on hypoxic pulmonary vasoconstriction. Eur.J.Pharmacol. 1999 PMID: 10422781
Coe The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in ther perinatal lamb. J.Pharmacol.Exp.Ther. 2002 PMID: 12130731
Doherty Discovery of a novel series of orally active non-peptide endothelin-A (ET_A) receptor-selective antagonists. J.Med.Chem. 1995 PMID: 7731010