CI 988

Tocris Bioscience, part of Bio-Techne | Catalog # 2607

COA / SDS

Potent and selective CCK2 antagonist

Key Product Details

Description:	Potent and selective CCK₂ antagonist
Alternative Names:	PD 134308
Chemical Name:	4-[[(1R)-2-[[(2R)-3-(1H-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	614.73

View Full Technical Details for CI 988

Technical Data
Citations

Biological Activity for CI 988

CI 988 is a potent and selective CCK₂ (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK₁ receptors (IC₅₀ values are 1.7 and 2717 nM for CCK₂ and CCK₁ respectively). Has negligible affinity at a range of other binding sites (IC₅₀ > 10 μM). Exhibits anxiolytic activity following oral administration.

Compound Libraries for CI 988

CI 988 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CI 988

M. Wt	614.73
Formula	C₃₅H₄₂N₄O₆
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	130332-27-3
PubChem ID	108187
InChi Key	FVQSSYMRZKLFDR-ZABPBAJSSA-N
Smiles	C[C@](NC(OC5C3CC(CC5C6)CC6C3)=O)(C(NC[C@@H]([C@]4=CC=CC=C4)NC(CCC(O)=O)=O)=O)CC2=CNC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CI 988

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	61.47	100

Preparing Stock Solutions for CI 988

The following data is based on the product molecular weight 614.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.13 mL	16.27 mL
5 mM	0.33 mL	1.63 mL	3.25 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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References for CI 988

References are publications that support the biological activity of the product.

Andre Involvement of cholecystokininergic systems in anxiety-induced hyperalgesia in male rats: behavioral and biochemical studies. J.Neurosci. 2005 PMID: 16135746
Hughes Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc.Natl.Acad.Sci.USA
Moody CI-988 inhibits growth of small cell lung cancer cells. J.Pharmacol.Exp.Ther. 2001 PMID: 11714907