CIA 1

Name: CIA 1
Brand: Tocris Bioscience
SKU: 7494

Tocris Bioscience, part of Bio-Techne | Catalog # 7494

COA / SDS

COUP-TFII inhibitor

Key Product Details

Description:	COUP-TFII inhibitor
Chemical Name:	N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	365.88

View Full Technical Details for CIA 1

Technical Data
Citations

Biological Activity for CIA 1

CIA 1 is an inhibitor of the nuclear receptor COUP-TFII (IC₅₀ ranged from 1.2 μM to 7.6 μM, in prostate cancer cell lines). In vitro, CIA 1 inhibits growth of multiple prostate cancer cell lines and suppresses COUP-TFII activity to regulate its target genes. In vivo, CIA 1 reduces tumor growth in prostate cancer xenograft mouse models.

Technical Data for CIA 1

M. Wt	365.88
Formula	C₁₇H₁₉N₃O₂S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1049691-47-5
PubChem ID	2974648
InChi Key	PYRMFONFWQTEGD-UHFFFAOYSA-N
Smiles	COC1=C(C=C(C=C1)CCNC2=C3C=C(SC3=NC=N2)C)OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CIA 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.32	20

Preparing Stock Solutions for CIA 1

The following data is based on the product molecular weight 365.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.67 mL	68.33 mL	136.66 mL
1 mM	2.73 mL	13.67 mL	27.33 mL
2 mM	1.37 mL	6.83 mL	13.67 mL
10 mM	0.27 mL	1.37 mL	2.73 mL

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References for CIA 1

References are publications that support the biological activity of the product.

Wang Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci.Adv. 2020 PMID: 32494682