Ciclesonide

Name: Ciclesonide
Brand: Tocris Bioscience
SKU: 6357

Tocris Bioscience, part of Bio-Techne | Catalog # 6357

COA / SDS

Glucocorticoid antiasthmatic prodrug

Key Product Details

Description:	Glucocorticoid antiasthmatic prodrug
Chemical Name:	(11β,16α)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione
Purity:	≥98% (HPLC)
Molecular Weight:	540.7

View Full Technical Details for Ciclesonide

Technical Data
Citations

Biological Activity for Ciclesonide

Ciclesonide is a glucocorticoid antiasthmatic prodrug; de-esterified in the lung to active metabolite. Anti-inflammatory. Also blocks replication of SARS-CoV-2 in Vero cells in vitro by targeting viral NSP-15 (EC₉₀ = 6.3μM)..

Compound Libraries for Ciclesonide

Ciclesonide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ciclesonide

M. Wt	540.7
Formula	C₃₂H₄₄O₇
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	126544-47-6
PubChem ID	6918155
InChi Key	LUKZNWIVRBCLON-GXOBDPJESA-N
Smiles	[H][C@@]1(C2CCCCC2)O[C@]3([H])C[C@@]4([H])[C@]5([H])CCC6=CC(C=C[C@]6(C)[C@@]5([H])[C@@H](O)C[C@]4(C)[C@]3(C(COC(C(C)C)=O)=O)O1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ciclesonide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	54.07	100
	ethanol	54.07	100

Preparing Stock Solutions for Ciclesonide

The following data is based on the product molecular weight 540.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.25 mL	18.49 mL
5 mM	0.37 mL	1.85 mL	3.70 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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Reconstitution Calculator

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References for Ciclesonide

References are publications that support the biological activity of the product.

Matsuyama The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting the viral replication-transcription complex in cultured cells. J.Virol. 2020 PMID: 33055254
Stoeck In vitro and in vivo anti-inflammatory activity of the new glucocorticoid cicles. J.Pharmacol.Exp.Ther. 2004 PMID: 14718604