Cilnidipine

Name: Cilnidipine
Brand: Tocris Bioscience
SKU: 2629

Tocris Bioscience, part of Bio-Techne | Catalog # 2629

(1)

Citations (3)

COA / SDS

Dual CaV1.x and CaV2.x blocker

Key Product Details

Chemical Name:	1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
Purity:	≥99%
Molecular Weight:	492.52 kDa

View Full Technical Details for Cilnidipine

Technical Data
Citations / Reviews (1)

Biological Activity for Cilnidipine

Cilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Technical Data for Cilnidipine

M. Wt	492.52 kDa
Formula	C₂₇H₂₈N₂O₇
Storage	Store at +4°C
Purity	≥99%
CAS Number	132203-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cilnidipine

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol

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References for Cilnidipine

References are publications that support the biological activity of the product.

Murai et al. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res., 2000;854:6 PMID: 10784100
Takahara et al. Neuroprotective effects of a dual L/N-type Ca²⁺ channel blocker cilnidipine in the rat focal brain ischemia model. Biol.Pharm.Bull., 2004;27:1388 PMID: 15340224
Nap et al. The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists. Fund.Clin.Pharmacol., 2004;18:309