Cilostamide

Name: Cilostamide
Brand: Tocris Bioscience
SKU: 0915

Tocris Bioscience, part of Bio-Techne | Catalog # 0915

Citations (52)

COA / SDS

PDE3 inhibitor

Key Product Details

Description:	PDE3 inhibitor
Alternative Names:	OCP 3689
Chemical Name:	N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
Purity:	≥97% (HPLC)
Molecular Weight:	342.44

View Full Technical Details for Cilostamide

Technical Data
Citations

Biological Activity for Cilostamide

Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC₅₀ values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC₅₀ = 16.8 μM); antithrombotic.

Technical Data for Cilostamide

M. Wt	342.44
Formula	C₂₀H₂₆N₂O₃
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	68550-75-4
PubChem ID	2753
InChi Key	UIAYVIIHMORPSJ-UHFFFAOYSA-N
Smiles	CN(C1CCCCC1)C(=O)CCCOC1=CC=C2NC(=O)C=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cilostamide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.85	20 with gentle warming

Preparing Stock Solutions for Cilostamide

The following data is based on the product molecular weight 342.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.60 mL	73.01 mL	146.01 mL
1 mM	2.92 mL	14.60 mL	29.20 mL
2 mM	1.46 mL	7.30 mL	14.60 mL
10 mM	0.29 mL	1.46 mL	2.92 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Cilostamide

References are publications that support the biological activity of the product.

Sudo Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem.Pharmacol. 2000 PMID: 10644042
Christensen and Torphy Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem.
Hidaki Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation. J.Pharmacol.Exp.Ther. 1979 PMID: 226672