CIM 0216

Name: CIM 0216
Brand: Tocris Bioscience
SKU: 5521

Tocris Bioscience, part of Bio-Techne | Catalog # 5521

Citations (12)

COA / SDS

Selective TRPM3 agonist

Key Product Details

Description:	Selective TRPM3 agonist
Chemical Name:	3,4-Dihydro-N-(5-methyl-3-isoxazolyl)-α-phenyl-1(2H)-quinolineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	347.41

View Full Technical Details for CIM 0216

Technical Data
Citations

Biological Activity for CIM 0216

CIM 0216 is a selective TRPM3 agonist. Exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. Stimulates insulin release from pancreatic islet cells in vitro. Evokes nocifensive behavior in mice.

Compound Libraries for CIM 0216

CIM 0216 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CIM 0216

M. Wt	347.41
Formula	C₂₁H₂₁N₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1031496-06-6
PubChem ID	42887770
InChi Key	KSEXDSJYVSEVGF-UHFFFAOYSA-N
Smiles	O=C(NC1=NOC(C)=C1)C(C2=CC=CC=C2)N(CCC3)C4=C3C=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CIM 0216

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.74	100

Preparing Stock Solutions for CIM 0216

The following data is based on the product molecular weight 347.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.88 mL	14.39 mL	28.78 mL
5 mM	0.58 mL	2.88 mL	5.76 mL
10 mM	0.29 mL	1.44 mL	2.88 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for CIM 0216

References are publications that support the biological activity of the product.

Held Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. Proc.Natl.Acad.Sci.U.S.A. 2015 PMID: 25733887