Cimetidine

Name: Cimetidine
Brand: Tocris Bioscience
SKU: 0902

Tocris Bioscience, part of Bio-Techne | Catalog # 0902

Citations (26)

COA / SDS

H2 antagonist, I1 agonist

Key Product Details

Description:	H₂ antagonist, I₁ agonist
Chemical Name:	N-Cyano-N'-methyl-N''-[2-[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine
Purity:	≥99% (HPLC)
Molecular Weight:	252.34

View Full Technical Details for Cimetidine

Technical Data
Citations

Biological Activity for Cimetidine

Cimetidine is a widely used H₂ histamine antagonist which has more recently been described as an inverse agonist. Also a potent I₁ imidazoline binding site ligand.

Compound Libraries for Cimetidine

Cimetidine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Cimetidine

M. Wt	252.34
Formula	C₁₀H₁₆N₆S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	51481-61-9
PubChem ID	2756
InChi Key	AQIXAKUUQRKLND-UHFFFAOYSA-N
Smiles	CN\C(NCCSCC1=C(C)NC=N1)=N\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cimetidine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		50
	DMSO	25.23	100

Preparing Stock Solutions for Cimetidine

The following data is based on the product molecular weight 252.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.96 mL	19.81 mL	39.63 mL
5 mM	0.79 mL	3.96 mL	7.93 mL
10 mM	0.40 mL	1.98 mL	3.96 mL
50 mM	0.08 mL	0.40 mL	0.79 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Cimetidine

References are publications that support the biological activity of the product.

Ernsberger A second generation of centrally acting antihypertensive agents act on putative I₁-imidazoline receptors. J.Cardiovasc.Pharmacol.
Smit Inverse agonism of histamine H₂ antagonists accounts for upregulation of spontaneously active receptors. Proc.Natl.Acad.Sci.U.S.A. 1996 PMID: 8692899
Tsoli The imidazoline I₁ receptor agonist, moxonidine, inhibits Ins secretion from isolated rat islets of langerhans. Eur.J.Pharmacol. 1995 PMID: 8549627
Hill Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 1990 PMID: 2164693

Product Documents for Cimetidine

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.