Cinacalcet hydrochloride

Name: Cinacalcet hydrochloride
Brand: Tocris Bioscience
SKU: 6170

Tocris Bioscience, part of Bio-Techne | Catalog # 6170

Citations (2)

COA / SDS

Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

Key Product Details

Chemical Name:	N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride
Purity:	≥98%

View Full Technical Details for Cinacalcet hydrochloride

Technical Data
Citations

Biological Activity for Cinacalcet hydrochloride

Cinacalcet hydrochloride is a calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC₅₀ = 87 nM) and L-type calcium channel blocker. Orally bioavailable.

Technical Data for Cinacalcet hydrochloride

Formula	C₂₂H₂₂F₃N.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	364782-34-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cinacalcet hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Cinacalcet hydrochloride

References are publications that support the biological activity of the product.

Ma et al. Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther., 2011;337:275 PMID: 21239511
Goodman et al. The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism. J.Am.Soc.Nephrol., 2002;13:1017 PMID: 11912261

Cinacalcet hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6170

Key Product Details

Biological Activity for Cinacalcet hydrochloride

Technical Data for Cinacalcet hydrochloride

Solubility for Cinacalcet hydrochloride

Dilution Calculator

Reconstitution Calculator

References for Cinacalcet hydrochloride

Product Documents for Cinacalcet hydrochloride

COA

Certificate of Analysis

SDS

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