Cisplatin

Name: Cisplatin
Brand: Tocris Bioscience
SKU: 2251

Tocris Bioscience, part of Bio-Techne | Catalog # 2251

(7)

Citations (145)

COA / SDS

Potent pro-apoptotic anticancer agent; activates caspase-3

Key Product Details

Chemical Name:

cis-Diaminodichloroplatinum

View Full Technical Details for Cisplatin

Technical Data
Citations / Reviews (7)

Biological Activity for Cisplatin

Cisplatin is a potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.

Technical Data for Cisplatin

Formula	Cl₂H₆N₂Pt
Storage	Store at RT
CAS Number	15663-27-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cisplatin

Solubility

Soluble Soluble to 5 mM in water with gentle warming

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References for Cisplatin

References are publications that support the biological activity of the product.

Robinson T, Liu J, Vizeacoumar F, Sun T, Maclean N, Egan S, Schimmer A, Datti A, Zacksenhaus E RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS ONE, 2013;8(11):e78641. 2013 PMID: 24265703
Seki et al. Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. Cancer Chemother.Pharmacol., 2000;45:199 PMID: 10663637
Nomura et al. Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells. Urol.Oncology, 2004;22:453
Duan et al. Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisp. and tumor necrosis factor α. Clin.Cancer Res., 2004;10:234 PMID: 14734475

Product Documents for Cisplatin

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Cisplatin, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov