Cl-4AS-1

Name: Cl-4AS-1
Brand: Tocris Bioscience
SKU: 3812

Tocris Bioscience, part of Bio-Techne | Catalog # 3812

Citations (7)

COA / SDS

Steroidal androgen receptor agonist

Key Product Details

Description:	Steroidal androgen receptor agonist
Chemical Name:	(4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	441.01

View Full Technical Details for Cl-4AS-1

Technical Data
Citations

Biological Activity for Cl-4AS-1

Cl-4AS-1 is a potent steroidal androgen receptor agonist (IC₅₀ = 12 nM). Mimics the action of 5α-dihydrotestosterone (DHT). Transactivates the mouse mammary tumor virus (MMTV) promoter; represses MMP1 promoter activity. Inhibits 5α-reductase type I and II (IC₅₀ values are 6 and 10 nM respectively).

Technical Data for Cl-4AS-1

M. Wt	441.01
Formula	C₂₆H₃₃ClN₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	188589-66-4
PubChem ID	90488881
InChi Key	CTVXDPDUOKQBKZ-BLIBDJTASA-N
Smiles	O=C(NC1=CC=CC=C1Cl)[C@H]2CC[C@@]3([H])[C@]4([H])CC[C@@]5([H])N(C)C(C=C[C@]5(C)[C@@]4([H])CC[C@@]32C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cl-4AS-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.41	10
	ethanol	4.41	10

Preparing Stock Solutions for Cl-4AS-1

The following data is based on the product molecular weight 441.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.68 mL	113.38 mL	226.75 mL
0.5 mM	4.54 mL	22.68 mL	45.35 mL
1 mM	2.27 mL	11.34 mL	22.68 mL
5 mM	0.45 mL	2.27 mL	4.54 mL

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References for Cl-4AS-1

References are publications that support the biological activity of the product.

Schmidt Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 2009 PMID: 19846549
Tolman 4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]. J.Steroid.Biochem.Mol.Biol. 1997 PMID: 9219921