Cladribine

Name: Cladribine
Brand: Tocris Bioscience
SKU: 5292

Tocris Bioscience, part of Bio-Techne | Catalog # 5292

Citations (4)

COA / SDS

Deoxyadenosine analog; pro-apoptotic

Key Product Details

Description:	Deoxyadenosine analog; pro-apoptotic
Alternative Names:	2-Chloro-2'-deoxyadenosine
Chemical Name:	(2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol
Purity:	≥99% (HPLC)
Molecular Weight:	285.69

View Full Technical Details for Cladribine

Technical Data
Citations

Biological Activity for Cladribine

Cladribine is an adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC₅₀ = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC₅₀ = 0.11 - 0.28 μM). Displays activity in vitro and in vivo. Orally bioavailable.

Technical Data for Cladribine

M. Wt	285.69
Formula	C₁₀H₁₂ClN₅O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	4291-63-8
PubChem ID	20279
InChi Key	PTOAARAWEBMLNO-KVQBGUIXSA-N
Smiles	OC[C@H]1O[C@@H](N2C=NC3=C2N=C(Cl)N=C3N)C[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cladribine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.57	100

Preparing Stock Solutions for Cladribine

The following data is based on the product molecular weight 285.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.50 mL	17.50 mL	35.00 mL
5 mM	0.70 mL	3.50 mL	7.00 mL
10 mM	0.35 mL	1.75 mL	3.50 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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Reconstitution Calculator

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References for Cladribine

References are publications that support the biological activity of the product.

Robak Older and new formulations of cladr. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat. Anticancer Drug Discov. 2006 PMID: 18221024
Seto Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest. 1985 PMID: 2579098
Bryson Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies. Drugs 1993 PMID: 7507037

Product Documents for Cladribine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Cladribine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov