Clemastine fumarate

Name: Clemastine fumarate
Brand: Tocris Bioscience
SKU: 1453

Tocris Bioscience, part of Bio-Techne | Catalog # 1453

Citations (7)

COA / SDS

H1 antagonist

Key Product Details

Description:	H₁ antagonist
Chemical Name:	(2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy]ethyl]-1-methyl-2-pyrrolidine fumarate
Purity:	≥98% (HPLC)
Molecular Weight:	459.97

View Full Technical Details for Clemastine fumarate

Technical Data
Citations

Biological Activity for Clemastine fumarate

Clemastine fumarate is a h₁-receptor antagonist. Enhances differentiation of oligodendrocyte progenitor cells into myelin basic protein-positive oligodendrocytes in vitro and promotes remyelination in vivo. Also displays antimuscarinic properties. Clinically-used antihistamine.

Compound Libraries for Clemastine fumarate

Clemastine fumarate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Clemastine fumarate

M. Wt	459.97
Formula	C₂₁H₂₆ClNO.C₄H₄O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	14976-57-9
PubChem ID	5281069
InChi Key	PMGQWSIVQFOFOQ-YKVZVUFRSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].CN1CCC[C@@H]1CCO[C@](C)(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Clemastine fumarate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.2	20

Preparing Stock Solutions for Clemastine fumarate

The following data is based on the product molecular weight 459.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.87 mL	54.35 mL	108.70 mL
1 mM	2.17 mL	10.87 mL	21.74 mL
2 mM	1.09 mL	5.44 mL	10.87 mL
10 mM	0.22 mL	1.09 mL	2.17 mL

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References for Clemastine fumarate

References are publications that support the biological activity of the product.

Hartmann Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects. Thorax 1981 PMID: 7330790
Nair and Schwartz Effect of histamine and histamine antagonists on natural and antibody-dependent cellular cytotoxicity of human lymphocytes in vitro. Cell.Immunol. 1983 PMID: 6225527
Dorsch Histamine1-histamine2 antagonism: effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitro. Agents Actions 1982 PMID: 6177209