CMPD-1

Name: CMPD-1
Brand: Tocris Bioscience
SKU: 2186

Tocris Bioscience, part of Bio-Techne | Catalog # 2186

(1)

Citations (7)

COA / SDS

Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor

Key Product Details

Chemical Name:	2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide
Purity:	≥99%
Molecular Weight:	349.4 kDa

View Full Technical Details for CMPD-1

Technical Data
Citations / Reviews (1)

Biological Activity for CMPD-1

CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent K_i = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.

Technical Data for CMPD-1

M. Wt	349.4 kDa
Formula	C₂₂H₂₀FNO₂
Storage	Store at RT
Purity	≥99%
CAS Number	41179-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CMPD-1

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for CMPD-1

References are publications that support the biological activity of the product.

Gurgis et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discovery, 2015;1:15028
Davidson et al. Discovery and characterisation of a substrate selective p38α inhibitor. Biochemistry, 2004;43:11658 PMID: 15362850