CMPI hydrochloride

Name: CMPI hydrochloride
Brand: Tocris Bioscience
SKU: 5963

Tocris Bioscience, part of Bio-Techne | Catalog # 5963

COA / SDS

Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs

Key Product Details

Description:	Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)₂(β2)₃, muscle-type and Torpedo nAChRs
Chemical Name:	3-(2-Chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	379.28

View Full Technical Details for CMPI hydrochloride

Technical Data
Citations

Biological Activity for CMPI hydrochloride

CMPI hydrochloride is a potent positive allosteric modulator of α4β2 nAChRs (EC₅₀ values are 20 and 18 nM for rat and human, respectively). Selective for hα4β2 over hα3β2, hα3β4 and hα7. Inhibits (α4)₂(β2)₃, muscle-type and Torpedo nAChRs (IC₅₀ values are 0.5, 0.7 and 0.2 μM, respectively), but not (α4)₃(β2)₂ receptors. Exhibits ability to photoincorporate into aliphatic and nucleophilic amino acid side chains.

Technical Data for CMPI hydrochloride

M. Wt	379.28
Formula	C₁₈H₁₉ClN₄O.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2250025-94-4
PubChem ID	127021040
InChi Key	WNKFVIPYZXTQBR-UHFFFAOYSA-N
Smiles	CC1=C(C2=CC(C3=C(C=CC=C3)Cl)=NO2)C=NN1C4CCNCC4.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CMPI hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	18.96	50
	DMSO	37.93	100

Preparing Stock Solutions for CMPI hydrochloride

The following data is based on the product molecular weight 379.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.18 mL	26.37 mL
5 mM	0.53 mL	2.64 mL	5.27 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for CMPI hydrochloride

References are publications that support the biological activity of the product.

Albrecht Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nicotinic acetylcholine receptor potentiators. Bioorg.Med.Chem.Lett. 2008 PMID: 18789861
Wang Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses. J.Biol.Chem. 2017 PMID: 28446611
Hamouda Photolabeling a nicotinic acetylcholine receptor (nAChR) with an (α4)₃(β2)₂ nAChR-selective positive allosteric modulator. Mol.Pharmacol. 2016 PMID: 26976945