CNQX

Name: CNQX
Brand: Tocris Bioscience
SKU: 0190
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0190

(1)

Citations (2057)

COA / SDS

Potent and selective non-NMDA iGluR antagonist

Key Product Details

Description:	Potent and selective non-NMDA iGluR antagonist
Alternative Names:	Cyanquixaline
Chemical Name:	6-Cyano-7-nitroquinoxaline-2,3-dione
Purity:	≥99% (HPLC)
Molecular Weight:	232.16

View Full Technical Details for CNQX

Technical Data
Citations / Reviews (1)

Biological Activity for CNQX

CNQX is an AMPA and kainate receptor antagonist (IC₅₀ values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC₅₀ = 25 μM). CNQX can be used to isolate GABA_A receptor-mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.

CNQX Disodium Salt (Cat. No. 1045) also available.

Compound Libraries for CNQX

CNQX is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CNQX

M. Wt	232.16
Formula	C₉H₄N₄O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	115066-14-3
PubChem ID	3721046
InChi Key	RPXVIAFEQBNEAX-UHFFFAOYSA-N
Smiles	[O-][N+](=O)C1=C(C=C2NC(=O)C(=O)NC2=C1)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CNQX

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.22	100

Preparing Stock Solutions for CNQX

The following data is based on the product molecular weight 232.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.31 mL	21.54 mL	43.07 mL
5 mM	0.86 mL	4.31 mL	8.61 mL
10 mM	0.43 mL	2.15 mL	4.31 mL
50 mM	0.09 mL	0.43 mL	0.86 mL

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Reconstitution Calculator

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References for CNQX

References are publications that support the biological activity of the product.

Watkins Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 1990 PMID: 2155495
King Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 1992 PMID: 1358390
Long Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 1990 PMID: 1976402
Honore Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 1988 PMID: 2899909