Colchicine

Name: Colchicine
Brand: Tocris Bioscience
SKU: 1364
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1364

(1)

Citations (32)

COA / SDS

Inhibitor of tubulin

Key Product Details

Description:	Inhibitor of tubulin
Chemical Name:	(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	399.44

View Full Technical Details for Colchicine

Technical Data
Citations / Reviews (1)

Biological Activity for Colchicine

Colchicine is a plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. Identified as a candidate for repurposing for COVID-19. Inhibits NLRP3 inflammasomes. Also decreases TNF-α receptor expression and reduces cytokine levels in macrophages. Anti-inflammatory.

Technical Data for Colchicine

M. Wt	399.44
Formula	C₂₂H₂₅NO₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	64-86-8
PubChem ID	2833
InChi Key	IAKHMKGGTNLKSZ-UHFFFAOYSA-N
Smiles	COC1=C(OC)C(OC)=C2C(CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Colchicine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	39.94	100
	DMSO	39.94	100

Preparing Stock Solutions for Colchicine

The following data is based on the product molecular weight 399.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.52 mL	25.04 mL
5 mM	0.50 mL	2.50 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Molarity Calculator

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Reconstitution Calculator

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References for Colchicine

References are publications that support the biological activity of the product.

Martinez The NLRP3 inflammasome and the emerging role of colch to inhibit atherosclerosis-associated inflammation. Atherosclerosis 2018 PMID: 29352570
Ribeiro The therapeutic potential of colch in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? Metabol.Open 2020 PMID: 32808940
Morselli Network medicine framework for identifying drug repurposing opportunities for COVID-19. Proc.Nat.Acad.Sci.U.S.A. 2021 PMID: 33906951
Hastie Interactions of colch. with tubulin. Pharmacol.Ther. 1991 PMID: 1792241
Burns Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 1992 PMID: 1544399
Bai Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colch. J.Biol.Chem. 1996 PMID: 8647876

Product Documents for Colchicine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Colchicine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov