Conduritol B epoxide

Name: Conduritol B epoxide
Brand: Tocris Bioscience
SKU: 7056

Tocris Bioscience, part of Bio-Techne | Catalog # 7056

Citations (2)

COA / SDS

Irreversible glucocerebrosidase (β-glucosidase) inhibitor; used to generate Gaucher disease models

Key Product Details

Description:	Irreversible glucocerebrosidase (β-glucosidase) inhibitor; used to generate Gaucher disease models
Chemical Name:	DL-1,2-Anhydro-myo-Inositol
Molecular Weight:	162.14

View Full Technical Details for Conduritol B epoxide

Technical Data
Citations

Biological Activity for Conduritol B epoxide

Conduritol B epoxide is an irreversible glucocerebrosidase (GBA) inhibitor (K_i = 53 μM; IC₅₀ = 4.28 - 9.49 μM). Also inhibitis lysosomal α-glucosidase. Used to generate animal models of Gaucher disease. Accelerates recovery of peripheral nerve injury in mice. Preserves motoneurons and ganglioside distribution at the neuromuscular junction, delays disease onset and improves motor function in a mouse ALS model.

Technical Data for Conduritol B epoxide

M. Wt	162.14
Formula	C₆H₁₀O₅
Storage	Store at -20°C
CAS Number	6090-95-5
PubChem ID	119054
InChi Key	ZHMWOVGZCINIHW-FTYOSCRSSA-N
Smiles	O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Conduritol B epoxide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	16.21	100
	DMSO	16.21	100

Preparing Stock Solutions for Conduritol B epoxide

The following data is based on the product molecular weight 162.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.17 mL	30.84 mL	61.68 mL
5 mM	1.23 mL	6.17 mL	12.34 mL
10 mM	0.62 mL	3.08 mL	6.17 mL
50 mM	0.12 mL	0.62 mL	1.23 mL

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References for Conduritol B epoxide

References are publications that support the biological activity of the product.

Kuo In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. FEBS J. 2019 PMID: 30600575
Henriques Inhibition of β-glucocerebrosidase activity preserves motor unit integrity in a mouse model of Amyotrophic Lateral Sclerosis. Sci.Rep. 2017 PMID: 28701774
Artola Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish. J.Am.Chem.Soc. 2019 PMID: 30811188
Witte Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nat.Chem.Biol. 2010 PMID: 21079602