CP 673451

Name: CP 673451
Brand: Tocris Bioscience
SKU: 5993

Tocris Bioscience, part of Bio-Techne | Catalog # 5993

Citations (7)

COA / SDS

Potent and selective PDGFR inhibitor

Key Product Details

Chemical Name:	1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
Purity:	≥98%

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Technical Data
Citations

Biological Activity for CP 673451

CP 673451 is a potent and selective PDGFR inhibitor (IC₅₀ values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.

Technical Data for CP 673451

Formula	C₂₄H₂₇N₅O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	343787-29-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 673451

Solubility

Soluble Soluble to 20 mM in DMSO

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References for CP 673451

References are publications that support the biological activity of the product.

A Shi, J Li, X Qiu, M Sabbah, S Boroumand, TC Huang, C Zhao, A Terzic, A Behfar, SL Moran TGF-&beta loaded exosome enhances ischemic wound healing in vitro and in vivo Theranostics, 2021;11(13):6616-6631. 2021 PMID: 33995680
Roberts et al. Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res., 2005;65:957 PMID: 15705896

CP 673451

Tocris Bioscience, part of Bio-Techne | Catalog # 5993

Key Product Details

Biological Activity for CP 673451

Technical Data for CP 673451

Solubility for CP 673451

Dilution Calculator

Reconstitution Calculator

References for CP 673451

Product Documents for CP 673451

COA

Certificate of Analysis

SDS

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