CP 96345

Name: CP 96345
Brand: Tocris Bioscience
SKU: 2893

Tocris Bioscience, part of Bio-Techne | Catalog # 2893

Citations (14)

COA / SDS

Potent and selective NK1 antagonist

Key Product Details

Chemical Name:	(2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine
Purity:	≥98%
Molecular Weight:	412.57 kDa

View Full Technical Details for CP 96345

Technical Data
Citations

Biological Activity for CP 96345

CP 96345 is a potent and selective non-peptide NK₁ receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.

Technical Data for CP 96345

M. Wt	412.57 kDa
Formula	C₂₈H₃₂N₂O
Storage	Store at -20°C
Purity	≥98%
CAS Number	132746-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 96345

Solubility

Soluble Soluble to 20 mM in DMSO with gentle warming

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References for CP 96345

References are publications that support the biological activity of the product.

A Taracanova, M Alevizos, A Karagkouni, Z Weng, E Norwitz, P Conti, SE Leeman, TC Theoharide SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):. 2017 PMID: 28461492
Snider et al. A potent nonpeptide antagonist of the substance P (NK1) receptor. Science, 1991;251:435 PMID: 1703323
Lembeck et al. The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol., 1992;105:527 PMID: 1378337
Bang et al. Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther., 2003;305:31 PMID: 12649350