CP 99994 dihydrochloride

Name: CP 99994 dihydrochloride
Brand: Tocris Bioscience
SKU: 3417

Tocris Bioscience, part of Bio-Techne | Catalog # 3417

Citations (4)

COA / SDS

High affinity NK1 antagonist

Key Product Details

Chemical Name:	(2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride
Purity:	≥99%
Molecular Weight:	369.33 kDa

View Full Technical Details for CP 99994 dihydrochloride

Technical Data
Citations

Biological Activity for CP 99994 dihydrochloride

CP 99994 dihydrochloride is a high affinity NK₁ antagonist (K_i = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC₅₀ = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.

Technical Data for CP 99994 dihydrochloride

M. Wt	369.33 kDa
Formula	C₁₉H₂₄N₂O.2HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	145148-39-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 99994 dihydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 50 mM in DMSO

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References for CP 99994 dihydrochloride

References are publications that support the biological activity of the product.

Shirahase et al. Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK₁ receptors and TXA₂. Br.J.Pharmacol., 1995;115:1215 PMID: 7582548
Duffy et al. Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther., 2002;301:536 PMID: 11961054
Lindstrom et al. Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy. J.Pharmacol.Exp.Ther., 2007;322:1286 PMID: 17575073