CPT 11

Name: CPT 11
Brand: Tocris Bioscience
SKU: 2688

Tocris Bioscience, part of Bio-Techne | Catalog # 2688

Citations (9)

COA / SDS

DNA topoisomerase I inhibitor; antitumor

Key Product Details

Chemical Name:	(4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic acid ester hydrochloride
Purity:	≥99%
Molecular Weight:	623.14 kDa

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Technical Data
Citations

Biological Activity for CPT 11

CPT 11 is an inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available (SN 38, Cat. No. 2684).

Technical Data for CPT 11

M. Wt	623.14 kDa
Formula	C₃₃H₃₈N₄O₆.HCl
Storage	Store at RT
Purity	≥99%
CAS Number	100286-90-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CPT 11

Solubility

Soluble Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO

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References for CPT 11

References are publications that support the biological activity of the product.

Kawato et al. Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. J.Pharm.Pharmacol., 1993;45:444 PMID: 8099964
Vassal et al. Therapeutic activity of CPT-11, a DNA topoisomerase I inhibitor against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts. Br.J.Cancer., 1996;74:537 PMID: 8761367