CPYPP

Name: CPYPP
Brand: Tocris Bioscience
SKU: 4568
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4568

(1)

Citations (7)

COA / SDS

DOCK2-Rac1 interaction inhibitor

Key Product Details

Description:	DOCK2-Rac1 interaction inhibitor
Chemical Name:	4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Purity:	≥98% (HPLC)
Molecular Weight:	324.76

View Full Technical Details for CPYPP

Technical Data
Citations / Reviews (1)

Biological Activity for CPYPP

CPYPP is a DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.

Technical Data for CPYPP

M. Wt	324.76
Formula	C₁₈H₁₃ClN₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	310460-39-0
PubChem ID	2248187
InChi Key	VVZJFICTTKPNCK-XWDZFIQBSA-N
Smiles	O=C(N(C3=CC=CC=C3)NC2=O)/C2=C\C=C\C1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CPYPP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.5	20

Preparing Stock Solutions for CPYPP

The following data is based on the product molecular weight 324.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	15.40 mL	76.98 mL	153.96 mL
1 mM	3.08 mL	15.40 mL	30.79 mL
2 mM	1.54 mL	7.70 mL	15.40 mL
10 mM	0.31 mL	1.54 mL	3.08 mL

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References for CPYPP

References are publications that support the biological activity of the product.

Laurin Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 23592719
Nishikimi Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem.Biol. 2012 PMID: 22520755