CS 640

Name: CS 640
Brand: Tocris Bioscience
SKU: 7982

Tocris Bioscience, part of Bio-Techne | Catalog # 7982

COA / SDS

Potent CaM kinase I inhibitor

Key Product Details

Description:	Potent CaM kinase I inhibitor
Chemical Name:	2-[(3S)-3-Amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]-5-pyrimidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	397.53

View Full Technical Details for CS 640

Technical Data
Citations

Biological Activity for CS 640

CS 640 is a potent calmodulin-dependent kinase I (CaMKI) inhibitor (IC₅₀ values are 1 nM, 1 nM, 3 nM and 8 nM at CAMK1A, CAMK1G, CAMK1B and CAMK1D respectively). Improves insulin sensitivity and glucose control in a mouse model of diet-induced obesity. Orally bioavailable in rodents.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the CS 640 probe summary on the SGC website.

Technical Data for CS 640

M. Wt	397.53
Formula	C₂₁H₃₁N₇O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2388506-83-8
PubChem ID	145946080
InChi Key	BWBUPDTUXQDHSX-AWEZNQCLSA-N
Smiles	NC(C1=CN=C(N2C[C@H](CCC2)N)N=C1NC3=CC(C(C)C)=NC(C(C)C)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CS 640

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	7.95	20
	ethanol	3.98	10

Preparing Stock Solutions for CS 640

The following data is based on the product molecular weight 397.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.58 mL	62.89 mL	125.78 mL
1 mM	2.52 mL	12.58 mL	25.16 mL
2 mM	1.26 mL	6.29 mL	12.58 mL
10 mM	0.25 mL	1.26 mL	2.52 mL

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Reconstitution Calculator

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References for CS 640

References are publications that support the biological activity of the product.

Fromont Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obesity in vivo mouse model. J.Med.Chem. 2020 PMID: 32433887