CST 967

Name: CST 967
Brand: Tocris Bioscience
SKU: 7801

Tocris Bioscience, part of Bio-Techne | Catalog # 7801

COA / SDS

Potent and selective USP7 Degrader (PROTAC®)

Key Product Details

Description:	Potent and selective USP7 Degrader (PROTAC^®)
Chemical Name:	3-(1-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)piperidin-4-yl)-N-(3-((4-hydroxy-1-((R)-3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)propanamide
Purity:	≥96% (HPLC)
Molecular Weight:	927.07

View Full Technical Details for CST 967

Technical Data
Citations

Biological Activity for CST 967

CST 967 is a potent and selective ubiquitin specific protease 7 (USP7) Degrader (PROTAC^®; D_max = 85% at 1μM, DC₅₀ = 17 nM).

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for CST 967

M. Wt	927.07
Formula	C₅₁H₅₈N₈O₉
Storage	Store at -20°C
Purity	≥96% (HPLC)
PubChem ID	170836153
InChi Key	REPLCRNGGWSKTN-JYQLQLLISA-N
Smiles	O=C1CCC(C(N1)=O)N2C(C3=C(C2=O)C=CC(N4CCC(CC4)C(N5CCC(CC5)CCC(NC6=CC(N=CN7CC8(CCN(CC8)C(C[C@H](C9=CC=CC=C9)C)=O)O)=C(C=C6)C7=O)=O)=O)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CST 967

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	92.71	100

Preparing Stock Solutions for CST 967

The following data is based on the product molecular weight 927.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.08 mL	5.39 mL	10.79 mL
5 mM	0.22 mL	1.08 mL	2.16 mL
10 mM	0.11 mL	0.54 mL	1.08 mL
50 mM	0.02 mL	0.11 mL	0.22 mL

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Reconstitution Calculator

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References for CST 967

References are publications that support the biological activity of the product.

Murgai Targeting the deubiquitinase USP7 for degradation with PROTACs. Chem.Commun. 2022 PMID: 35852517