CU CPT 9a

Name: CU CPT 9a
Brand: Tocris Bioscience
SKU: 6479

Tocris Bioscience, part of Bio-Techne | Catalog # 6479

COA / SDS

Highly potent TLR8 inhibitor

Key Product Details

Description:	Highly potent TLR8 inhibitor
Chemical Name:	2-Methyl-4-(7-methoxy-4-quinolinyl)phenol
Purity:	≥98% (HPLC)
Molecular Weight:	265.31

View Full Technical Details for CU CPT 9a

Technical Data
Citations

Biological Activity for CU CPT 9a

CU CPT 9a is a potent TLR8 inhibitor (IC₅₀ = 0.5 nM and K_d = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

Licensing Information

Sold under license from the University of Colorado

Compound Libraries for CU CPT 9a

CU CPT 9a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for CU CPT 9a

M. Wt	265.31
Formula	C₁₇H₁₅NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2165340-32-7
PubChem ID	135567383
InChi Key	HNYBTVKYLVLWCB-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C(C3=CC(C)=C(C=C3)O)=CC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CU CPT 9a

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.53	100
	ethanol	5.31	20

Preparing Stock Solutions for CU CPT 9a

The following data is based on the product molecular weight 265.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.77 mL	18.85 mL	37.69 mL
5 mM	0.75 mL	3.77 mL	7.54 mL
10 mM	0.38 mL	1.88 mL	3.77 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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References for CU CPT 9a

References are publications that support the biological activity of the product.

Zhang Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat.Chem.Biol. 2018 PMID: 29155428