Cucurbitacin I

Name: Cucurbitacin I
Brand: Tocris Bioscience
SKU: 1571

Tocris Bioscience, part of Bio-Techne | Catalog # 1571

Citations (21)

COA / SDS

Selective inhibitor of STAT3/JAK2 signaling

Key Product Details

Description:	Selective inhibitor of STAT3/JAK2 signaling
Alternative Names:	Elatericin B,JSI 124
Chemical Name:	(9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
Purity:	≥95% (HPLC)
Molecular Weight:	514.65

View Full Technical Details for Cucurbitacin I

Technical Data
Citations

Biological Activity for Cucurbitacin I

Cucurbitacin I is a selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Technical Data for Cucurbitacin I

M. Wt	514.65
Formula	C₃₀H₄₂O₇
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2222-07-3
PubChem ID	5281321
InChi Key	NISPVUDLMHQFRQ-MKIKIEMVSA-N
Smiles	OC(C)(C)/C=C/C([C@@](O)(C)[C@@]3([H])[C@H](O)C[C@@]([C@@](C)3C4)(C)[C@]2([H])CC=C1C(C)(C)C(C(O)=C[C@]([H])1[C@@](C)2C4=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cucurbitacin I

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.15	10

Preparing Stock Solutions for Cucurbitacin I

The following data is based on the product molecular weight 514.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.43 mL	97.15 mL	194.31 mL
0.5 mM	3.89 mL	19.43 mL	38.86 mL
1 mM	1.94 mL	9.72 mL	19.43 mL
5 mM	0.39 mL	1.94 mL	3.89 mL

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References for Cucurbitacin I

References are publications that support the biological activity of the product.

Nefedova Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res. 2005 PMID: 16230418
Dziennis Role of signal transducer and activator of transcription-3 in OE-mediated neuroprotection. J.Neurosci. 2007 PMID: 17611279
Blaskovich Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 2003 PMID: 12649187