CVT 10216

Name: CVT 10216
Brand: Tocris Bioscience
SKU: 5164

Tocris Bioscience, part of Bio-Techne | Catalog # 5164

Citations (3)

COA / SDS

Potent and selective ALDH2 inhibitor

Key Product Details

Description:	Potent and selective ALDH2 inhibitor
Chemical Name:	3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	465.48

View Full Technical Details for CVT 10216

Technical Data
Citations

Biological Activity for CVT 10216

CVT 10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC₅₀ values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.

Compound Libraries for CVT 10216

CVT 10216 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CVT 10216

M. Wt	465.48
Formula	C₂₄H₁₉NO₇S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1005334-57-5
PubChem ID	23661666
InChi Key	YYOOFJZTRCPVFD-UHFFFAOYSA-N
Smiles	O=C2C1=CC=C(OCC4=CC(C(O)=O)=CC=C4)C=C1OC=C2C3=CC=C(NS(=O)(C)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CVT 10216

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.55	100
	1eq. NaOH	23.27	50

Preparing Stock Solutions for CVT 10216

The following data is based on the product molecular weight 465.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.30 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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Reconstitution Calculator

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References for CVT 10216

References are publications that support the biological activity of the product.

Yao Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of DA synthesis. Nat.Med. 2010 PMID: 20729865
Overstreet A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacol.Biochem.Behav. 2009 PMID: 19747934