CX 546

Name: CX 546
Brand: Tocris Bioscience
SKU: 2980

Tocris Bioscience, part of Bio-Techne | Catalog # 2980

Citations (11)

COA / SDS

AMPA potentiator

Key Product Details

Description:	AMPA potentiator
Chemical Name:	(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
Purity:	≥99% (HPLC)
Molecular Weight:	247.29

View Full Technical Details for CX 546

Technical Data
Citations

Biological Activity for CX 546

CX 546 is an AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats. Neuroprotective in mice undergoing repeat ketamine anesthesia.

Technical Data for CX 546

M. Wt	247.29
Formula	C₁₄H₁₇NO₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	215923-54-9
PubChem ID	2890
InChi Key	LJUNPHMOGNFFOS-UHFFFAOYSA-N
Smiles	O=C(N3CCCCC3)C2=CC1=C(C=C2)OCCO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CX 546

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.73	100
	ethanol	24.73	100

Preparing Stock Solutions for CX 546

The following data is based on the product molecular weight 247.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.04 mL	20.22 mL	40.44 mL
5 mM	0.81 mL	4.04 mL	8.09 mL
10 mM	0.40 mL	2.02 mL	4.04 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

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References for CX 546

References are publications that support the biological activity of the product.

Huang Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. Sci.Transl.Med. 2016 PMID: 27334260
O'Neill AMPA receptor potentiators for the treatment of CNS disorders. Curr.Drug Targets CNS Neurol.Disord. 2004 PMID: 15180479
Shimazaki Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats. Eur.J.Pharmacol. 2007 PMID: 17727837
Nagararjan Mechanism and impact of allosteric AMPA receptor modulation by the ampakine TM CX546. Neuropharmacology. 2001 PMID: 11640919