CX 614

Name: CX 614
Brand: Tocris Bioscience
SKU: 5149

Tocris Bioscience, part of Bio-Techne | Catalog # 5149

Citations (8)

COA / SDS

Positive allosteric modulator of AMPA receptors

Key Product Details

Description:	Positive allosteric modulator of AMPA receptors
Chemical Name:	2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one
Purity:	≥99% (HPLC)
Molecular Weight:	247.25

View Full Technical Details for CX 614

Technical Data
Citations

Biological Activity for CX 614

CX 614 is an AMPAkine; positive allosteric modulator of AMPA. Prototypical benzamide which occupies subsite A only. Modulates channel deactivation and desensitization.

Compound Libraries for CX 614

CX 614 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CX 614

M. Wt	247.25
Formula	C₁₃H₁₃NO₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	191744-13-5
PubChem ID	6451148
InChi Key	RQEPVMAYUINZRE-UHFFFAOYSA-N
Smiles	O=C2N4C(CCC4)OC1=CC3=C(OCCO3)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CX 614

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.73	100
	ethanol	12.36	50

Preparing Stock Solutions for CX 614

The following data is based on the product molecular weight 247.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.04 mL	20.22 mL	40.44 mL
5 mM	0.81 mL	4.04 mL	8.09 mL
10 mM	0.40 mL	2.02 mL	4.04 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

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References for CX 614

References are publications that support the biological activity of the product.

Timm Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol. 2011 PMID: 21543522
Hennegriff Stable expression of recombinant AMPA receptor subunits: binding affinities and effects of allosteric modulators. J.Neurochem. 1997 PMID: 9166736
Harms Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology 2013 PMID: 22735771