CY 208-243

Name: CY 208-243
Brand: Tocris Bioscience
SKU: 1249

Tocris Bioscience, part of Bio-Techne | Catalog # 1249

Citations (4)

COA / SDS

Selective D1-like agonist

Key Product Details

Description:	Selective D₁-like agonist
Chemical Name:	(-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin
Molecular Weight:	274.36

View Full Technical Details for CY 208-243

Technical Data
Citations

Biological Activity for CY 208-243

CY 208-243 is a centrally active dopamine D₁ receptor agonist, selective over D₂ receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC₅₀ of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models.

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data for CY 208-243

M. Wt	274.36
Formula	C₁₉H₁₈N₂
Storage	Store at RT
CAS Number	100999-26-6
PubChem ID	58144
InChi Key	WRNKIDLXXXIELU-IEBWSBKVSA-N
Smiles	[H][C@]4([C@@]([H])3C5=C(C=CC=C5)CN4C)CC1=CNC2=C1C3=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CY 208-243

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for CY 208-243

The following data is based on the product molecular weight 274.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.64 mL	18.22 mL	36.45 mL
5 mM	0.73 mL	3.64 mL	7.29 mL
10 mM	0.36 mL	1.82 mL	3.64 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

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References for CY 208-243

References are publications that support the biological activity of the product.

Temlett Antiparkinsonian activity of CY 208-243, a partial D-1 DA receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease. Mov.Disord. 1989 PMID: 2571082
Markstein Pharmacologic properties of CY 208-243, a novel D1 agonist. Progress in Catecholamine Research. Part B. Centra
Andersen and Jansen DA receptor agonists: selectivity and DA D₁ receptor efficacy. Eur.J.Pharmacol. 1990 PMID: 1973652